Scaling of DLD devices for cell fractionation down to a single column for ultrahigh throughput per area

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the scaling of Deterministic Lateral Displacement (DLD) devices for cell fractionation to smaller array sizes (fewer rows and columns of bumping obstacles) to increase the throughput per area, going all the way to a DLD with only a single column of obstacles. A device with one column of 14 bumping features (area of 0.6mm2) can separate particles with diameters of 4.8μm and 9.9μm at 30μL/min with >99% efficiency, representing a 10X improvement in throughput per area compared to prior cell fractionation devices in this size range.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages647-648
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

Keywords

  • Deterministic Lateral Displacement (DLD)
  • Separation

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