Sacrificial polymers for nanofluidic channels in biological applications

Wanli Li; Jonas O. Tegenfeldt; Lei Chen; Robert H. Austin; Stephen Y. Chou; Paul A. Kohl; Jeff Krotine; James C. Sturm

doi:10.1088/0957-4484/14/6/302

Sacrificial polymers for nanofluidic channels in biological applications

Wanli Li, Jonas O. Tegenfeldt, Lei Chen, Robert H. Austin, Stephen Y. Chou, Paul A. Kohl, Jeff Krotine, James C. Sturm

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Chip based bio/chemical analysis relies on networks of fluidic channels that are connected to reaction chambers and sensors. For sensitive detection it is important to scale down the size of the channels so that they approach the relevant length scales of the molecules of interest. Here we have made sealed channels on the 100 nm scale using nanoimprinting to pattern the sacrificial polymer polynorbornene over areas of several square centimetres. We have combined channels of different cross sections and we have shown that the nanochannels can be made hydrophilic with DNA transported electrophoretically in these self-sealed channels.

Original language	English (US)
Pages (from-to)	578-583
Number of pages	6
Journal	Nanotechnology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1088/0957-4484/14/6/302
State	Published - Jun 2003

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1088/0957-4484/14/6/302

Cite this

@article{6c8bb97ef95e4c78a4d582b89f58bada,

title = "Sacrificial polymers for nanofluidic channels in biological applications",

abstract = "Chip based bio/chemical analysis relies on networks of fluidic channels that are connected to reaction chambers and sensors. For sensitive detection it is important to scale down the size of the channels so that they approach the relevant length scales of the molecules of interest. Here we have made sealed channels on the 100 nm scale using nanoimprinting to pattern the sacrificial polymer polynorbornene over areas of several square centimetres. We have combined channels of different cross sections and we have shown that the nanochannels can be made hydrophilic with DNA transported electrophoretically in these self-sealed channels.",

author = "Wanli Li and Tegenfeldt, {Jonas O.} and Lei Chen and Austin, {Robert H.} and Chou, {Stephen Y.} and Kohl, {Paul A.} and Jeff Krotine and Sturm, {James C.}",

year = "2003",

month = jun,

doi = "10.1088/0957-4484/14/6/302",

language = "English (US)",

volume = "14",

pages = "578--583",

journal = "Nanotechnology",

issn = "0957-4484",

publisher = "IOP Publishing Ltd.",

number = "6",

}

TY - JOUR

T1 - Sacrificial polymers for nanofluidic channels in biological applications

AU - Li, Wanli

AU - Tegenfeldt, Jonas O.

AU - Chen, Lei

AU - Austin, Robert H.

AU - Chou, Stephen Y.

AU - Kohl, Paul A.

AU - Krotine, Jeff

AU - Sturm, James C.

PY - 2003/6

Y1 - 2003/6

N2 - Chip based bio/chemical analysis relies on networks of fluidic channels that are connected to reaction chambers and sensors. For sensitive detection it is important to scale down the size of the channels so that they approach the relevant length scales of the molecules of interest. Here we have made sealed channels on the 100 nm scale using nanoimprinting to pattern the sacrificial polymer polynorbornene over areas of several square centimetres. We have combined channels of different cross sections and we have shown that the nanochannels can be made hydrophilic with DNA transported electrophoretically in these self-sealed channels.

AB - Chip based bio/chemical analysis relies on networks of fluidic channels that are connected to reaction chambers and sensors. For sensitive detection it is important to scale down the size of the channels so that they approach the relevant length scales of the molecules of interest. Here we have made sealed channels on the 100 nm scale using nanoimprinting to pattern the sacrificial polymer polynorbornene over areas of several square centimetres. We have combined channels of different cross sections and we have shown that the nanochannels can be made hydrophilic with DNA transported electrophoretically in these self-sealed channels.

UR - http://www.scopus.com/inward/record.url?scp=0037529339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037529339&partnerID=8YFLogxK

U2 - 10.1088/0957-4484/14/6/302

DO - 10.1088/0957-4484/14/6/302

M3 - Article

AN - SCOPUS:0037529339

SN - 0957-4484

VL - 14

SP - 578

EP - 583

JO - Nanotechnology

JF - Nanotechnology

IS - 6

ER -

Sacrificial polymers for nanofluidic channels in biological applications

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this