Roseochelin B, an algaecidal natural product synthesized by the roseobacter phaeobacter inhibens in response to algal sinapic acid

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Abstract

The secondary metabolome of the representative Roseobacter, Phaeobacter inhibens, was examined in response to algal sinapic acid. In addition to roseobacticides, sinapic acid induced the production of two new natural products, roseochelin A and B, which were characterized by NMR and X-ray crystallography. Functional assays showed that roseochelin B binds iron and is algaecidal against the algal host Emiliania huxleyi. It appears to be produced by a rarely observed combination of nonenzymatic and enzymatic transformations.

Original languageEnglish (US)
Pages (from-to)5138-5141
Number of pages4
JournalOrganic Letters
Volume19
Issue number19
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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