Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.
|Original language||English (US)|
|Journal||Physical review letters|
|State||Published - Jun 20 2016|
All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)