Abstract

Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.

Original languageEnglish (US)
Article number258101
JournalPhysical review letters
Volume116
Issue number25
DOIs
StatePublished - Jun 20 2016

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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