Role of the Membrane for Mechanosensing by Tethered Channels

Benedikt Sabass, Howard A. Stone

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.

Original languageEnglish (US)
Article number258101
JournalPhysical review letters
Volume116
Issue number25
DOIs
StatePublished - Jun 20 2016

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy

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