Abstract
Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.
Original language | English (US) |
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Article number | 258101 |
Journal | Physical review letters |
Volume | 116 |
Issue number | 25 |
DOIs | |
State | Published - Jun 20 2016 |
All Science Journal Classification (ASJC) codes
- General Physics and Astronomy