Role of molecular size in ratchet fractionation

Lotien Richard Huang, Pascal Silberzan, Jonas O. Tegenfeldt, Edward C. Cox, James C. Sturm, R. Austin, Harold Craighead

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Abstract

DNA molecules of three sizes (411 bp, 48.5 kbp, and 167 kbp) were analyzed in an asymmetric obstacle array. Array boundary conditions of carefully aligned current were used to create very straight bands over long distances, and the separation of molecules was studied as a function of drift velocity. Evidence was obtained that fractionation in asymmetric obstacle arrays requires that the molecular size be comparable with the barrier gap size.

Original languageEnglish (US)
Article number178301
Pages (from-to)178301/1-178301/4
JournalPhysical review letters
Volume89
Issue number17
DOIs
StatePublished - Oct 21 2002

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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    Huang, L. R., Silberzan, P., Tegenfeldt, J. O., Cox, E. C., Sturm, J. C., Austin, R., & Craighead, H. (2002). Role of molecular size in ratchet fractionation. Physical review letters, 89(17), 178301/1-178301/4. [178301]. https://doi.org/10.1103/PhysRevLett.89.178301