Role of immune molecules in the establishment and plasticity of glutamatergic synapses

Lawrence Fourgeaud, Lisa M. Boulanger

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

An increasing number of studies support an unexpected role for immune molecules in regulating healthy brain functions during development and in adulthood. Here we review the roles of specic immune molecules (including cytokines, components of the complement cascade, and members of the major histocompatibility complex class I family and their receptors) in the formation and plasticity of glutamatergic synapses. These ndings add a new dimension to our understanding of neural-immune interactions, and suggest novel molecular mechanisms that may underlie the modication of glutamatergic synapses in both normal and pathological states.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalEuropean Journal of Neuroscience
Volume32
Issue number2
DOIs
StatePublished - Jul 1 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Neural plasticity
  • Neural-immune
  • Neuronal activity
  • Neuronal development
  • Neurosciences

Fingerprint Dive into the research topics of 'Role of immune molecules in the establishment and plasticity of glutamatergic synapses'. Together they form a unique fingerprint.

  • Cite this