Role of Central Serotonin in Impulsivity and Compulsivity: Comparative Studies in Experimental Animals and Humans

Trevor W. Robbins, Molly J. Crockett

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Abstract

The involvement of serotonin in impulsivity (the tendency to respond prematurely) and compulsivity (the tendency to perseverate) is reviewed from the joint perspective of animal and human studies. Evidence is provided to support a role for serotonin in some forms of impulsivity, but not others, and in compulsivity. However, it is difficult to accommodate these roles into a common scheme implicating behavioral inhibition. The implications for neuropsychiatric disorders such as obsessive-compulsive disorder are considered.

Original languageEnglish (US)
Title of host publicationHandbook of Behavioral Neuroscience
Pages415-427
Number of pages13
EditionC
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Publication series

NameHandbook of Behavioral Neuroscience
NumberC
Volume21
ISSN (Print)1569-7339

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Keywords

  • ADHD
  • behavioral inhibition
  • compulsivity
  • impulsivity
  • obsessive-compulsive disorder
  • prefrontal cortex
  • striatum

Fingerprint

Dive into the research topics of 'Role of Central Serotonin in Impulsivity and Compulsivity: Comparative Studies in Experimental Animals and Humans'. Together they form a unique fingerprint.

Cite this