Ribosomal route to small-molecule diversity

Ma Diarey B. Tianero, Mohamed S. Donia, Travis S. Young, Peter G. Schultz, Eric W. Schmidt

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

The cyanobactin ribosomal peptide (RP) natural product pathway was manipulated to incorporate multiple tandem mutations and non-proteinogenic amino acids, using eight heterologous components simultaneously expressed in Escherichia coli. These studies reveal the potential of RPs for the rational synthesis of complex, new small molecules over multiple-step biosynthetic pathways using simple genetic engineering.

Original languageEnglish (US)
Pages (from-to)418-425
Number of pages8
JournalJournal of the American Chemical Society
Volume134
Issue number1
DOIs
StatePublished - Jan 11 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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  • Cite this

    Tianero, M. D. B., Donia, M. S., Young, T. S., Schultz, P. G., & Schmidt, E. W. (2012). Ribosomal route to small-molecule diversity. Journal of the American Chemical Society, 134(1), 418-425. https://doi.org/10.1021/ja208278k