Rhodium(III)-catalyzed intramolecular hydroarylation, amidoarylation, and heck-type reaction: Three distinct pathways determined by an amide directing group

Tyler A. Davis, Todd K. Hyster, Tomislav Rovis

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

The amide decides: Three different rhodium(III)-catalyzed reaction pathways of a wide variety of tethered alkenes can be accessed through changing the amide directing group. This provides an efficient route to a myriad of complex polycyclic products, many containing newly formed all-carbon quaternary centers. Amidoarylations can diastereoselectively deliver products with up to three contiguous stereocenters.

Original languageEnglish (US)
Pages (from-to)14181-14185
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number52
DOIs
StatePublished - Dec 23 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • C-H activation
  • Heck-type reaction
  • amidoarylation
  • hydroarylation
  • rhodium

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