Abstract
We have developed a synthesis of 4-substituted isoquinolones from the rhodium(III)-catalyzed, C-H activation mediated coupling of O-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic system, which can open under acidic conditions to generate the desired isoquinolone.
| Original language | English (US) |
|---|---|
| Article number | ST-2013-S0543 |
| Pages (from-to) | 1842-1844 |
| Number of pages | 3 |
| Journal | Synlett |
| Volume | 24 |
| Issue number | 14 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
Keywords
- C-H activation
- cyclopropene
- donor-acceptor cyclopropane
- heterocycles
- isoquinolone