Abstract
We have developed a synthesis of 4-substituted isoquinolones from the rhodium(III)-catalyzed, C-H activation mediated coupling of O-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic system, which can open under acidic conditions to generate the desired isoquinolone.
Original language | English (US) |
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Article number | ST-2013-S0543 |
Pages (from-to) | 1842-1844 |
Number of pages | 3 |
Journal | Synlett |
Volume | 24 |
Issue number | 14 |
DOIs | |
State | Published - 2013 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
Keywords
- C-H activation
- cyclopropene
- donor-acceptor cyclopropane
- heterocycles
- isoquinolone