Rhodium(III)-catalyzed C-H activation mediated synthesis of isoquinolones from amides and cyclopropenes

Todd K. Hyster, Tomislav Rovis

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We have developed a synthesis of 4-substituted isoquinolones from the rhodium(III)-catalyzed, C-H activation mediated coupling of O-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic system, which can open under acidic conditions to generate the desired isoquinolone.

Original languageEnglish (US)
Article numberST-2013-S0543
Pages (from-to)1842-1844
Number of pages3
JournalSynlett
Volume24
Issue number14
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Keywords

  • C-H activation
  • cyclopropene
  • donor-acceptor cyclopropane
  • heterocycles
  • isoquinolone

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