An efficient strategy for the oxidative carbonylation of benzamides via C-H/N-H activation to form phthalimides has been developed. The reaction utilizes Rh(III) catalyst in the presence of Ag(I) oxidant, and is proposed to proceed by N-H metalation of the amide followed by ortho C-H activation. The resultant rhodacycle undergoes CO insertion to form phthalimides in good to excellent yields.
All Science Journal Classification (ASJC) codes
- General Chemistry
- General Chemical Engineering