An efficient strategy for the oxidative carbonylation of benzamides via C-H/N-H activation to form phthalimides has been developed. The reaction utilizes Rh(III) catalyst in the presence of Ag(I) oxidant, and is proposed to proceed by N-H metalation of the amide followed by ortho C-H activation. The resultant rhodacycle undergoes CO insertion to form phthalimides in good to excellent yields.
|Original language||English (US)|
|Journal||ACS National Meeting Book of Abstracts|
|State||Published - Dec 1 2011|
|Event||242nd ACS National Meeting and Exposition - Denver, CO, United States|
Duration: Aug 28 2011 → Sep 1 2011
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)