Rhodium-carbenoid-mediated intermolecular O-H insertion reactions: A dramatic additive effect. Application in the synthesis of an ascomycin derivative

Todd D. Nelson, Zhiguo Jake Song, Andrew S. Thompson, Mangzhu Zhao, Anthony Demarco, Robert A. Reamer, Martha F. Huntington, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

A catalyst system of Rh2(oct)4/DIPEA or TMU allows for the rapid construction of α-alkoxyketones from the corresponding α-diazo ketone and alcohol. This methodology was applied to the synthesis of immunoregulant 1. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1877-1881
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number12
DOIs
StatePublished - Mar 18 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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