Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

Jian Da Lin; Joseph C. Devlin; Frank Yeung; Caroline McCauley; Jacqueline M. Leung; Ying Han Chen; Alex Cronkite; Christina Hansen; Charlotte Drake-Dunn; Kelly V. Ruggles; Ken Cadwell; Andrea L. Graham; P'ng Loke

doi:10.1016/j.chom.2020.03.001

Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

Jian Da Lin
, Joseph C. Devlin
, Frank Yeung
, Caroline McCauley
, Jacqueline M. Leung
, Ying Han Chen
, Alex Cronkite
, Christina Hansen
, Charlotte Drake-Dunn
, Kelly V. Ruggles
, Ken Cadwell
, Andrea L. Graham
, P'ng Loke

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The effect of genetics verses environment on immunity is incompletely understood. By releasing laboratory mice carrying IBD susceptibility genes into the outdoors, Lin et al. find that exposure to environmental microbes promotes variation in immune cell populations, whereas cytokine responses to microbial stimulation are affected more by genetic IBD susceptibility.

Original language	English (US)
Pages (from-to)	830-840.e4
Journal	Cell Host and Microbe
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.chom.2020.03.001
State	Published - May 13 2020

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Virology

Keywords

immune variation
inflammatory bowel disease
machine learning model
multi-omic data integration
rewilded mice

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10.1016/j.chom.2020.03.001

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Lin, J. D., Devlin, J. C., Yeung, F., McCauley, C., Leung, J. M., Chen, Y. H., Cronkite, A., Hansen, C., Drake-Dunn, C., Ruggles, K. V., Cadwell, K., Graham, A. L., & Loke, P. (2020). Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition. Cell Host and Microbe, 27(5), 830-840.e4. https://doi.org/10.1016/j.chom.2020.03.001

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title = "Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition",

abstract = "The effect of genetics verses environment on immunity is incompletely understood. By releasing laboratory mice carrying IBD susceptibility genes into the outdoors, Lin et al. find that exposure to environmental microbes promotes variation in immune cell populations, whereas cytokine responses to microbial stimulation are affected more by genetic IBD susceptibility.",

keywords = "immune variation, inflammatory bowel disease, machine learning model, multi-omic data integration, rewilded mice",

author = "Lin, \{Jian Da\} and Devlin, \{Joseph C.\} and Frank Yeung and Caroline McCauley and Leung, \{Jacqueline M.\} and Chen, \{Ying Han\} and Alex Cronkite and Christina Hansen and Charlotte Drake-Dunn and Ruggles, \{Kelly V.\} and Ken Cadwell and Graham, \{Andrea L.\} and P'ng Loke",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = may,

day = "13",

doi = "10.1016/j.chom.2020.03.001",

language = "English (US)",

volume = "27",

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journal = "Cell Host and Microbe",

issn = "1931-3128",

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}

Lin, JD, Devlin, JC, Yeung, F, McCauley, C, Leung, JM, Chen, YH, Cronkite, A, Hansen, C, Drake-Dunn, C, Ruggles, KV, Cadwell, K, Graham, AL & Loke, P 2020, 'Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition', Cell Host and Microbe, vol. 27, no. 5, pp. 830-840.e4. https://doi.org/10.1016/j.chom.2020.03.001

TY - JOUR

T1 - Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

AU - Lin, Jian Da

AU - Devlin, Joseph C.

AU - Yeung, Frank

AU - McCauley, Caroline

AU - Leung, Jacqueline M.

AU - Chen, Ying Han

AU - Cronkite, Alex

AU - Hansen, Christina

AU - Drake-Dunn, Charlotte

AU - Ruggles, Kelly V.

AU - Cadwell, Ken

AU - Graham, Andrea L.

AU - Loke, P'ng

PY - 2020/5/13

Y1 - 2020/5/13

N2 - The effect of genetics verses environment on immunity is incompletely understood. By releasing laboratory mice carrying IBD susceptibility genes into the outdoors, Lin et al. find that exposure to environmental microbes promotes variation in immune cell populations, whereas cytokine responses to microbial stimulation are affected more by genetic IBD susceptibility.

AB - The effect of genetics verses environment on immunity is incompletely understood. By releasing laboratory mice carrying IBD susceptibility genes into the outdoors, Lin et al. find that exposure to environmental microbes promotes variation in immune cell populations, whereas cytokine responses to microbial stimulation are affected more by genetic IBD susceptibility.

KW - immune variation

KW - inflammatory bowel disease

KW - machine learning model

KW - multi-omic data integration

KW - rewilded mice

UR - https://www.scopus.com/pages/publications/85082940240

UR - https://www.scopus.com/pages/publications/85082940240#tab=citedBy

U2 - 10.1016/j.chom.2020.03.001

DO - 10.1016/j.chom.2020.03.001

M3 - Article

C2 - 32209431

AN - SCOPUS:85082940240

SN - 1931-3128

VL - 27

SP - 830-840.e4

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 5

ER -

Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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