Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

Jian Da Lin, Joseph C. Devlin, Frank Yeung, Caroline McCauley, Jacqueline M. Leung, Ying Han Chen, Alex Cronkite, Christina Hansen, Charlotte Drake-Dunn, Kelly V. Ruggles, Ken Cadwell, Andrea L. Graham, P'ng Loke

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effect of genetics verses environment on immunity is incompletely understood. By releasing laboratory mice carrying IBD susceptibility genes into the outdoors, Lin et al. find that exposure to environmental microbes promotes variation in immune cell populations, whereas cytokine responses to microbial stimulation are affected more by genetic IBD susceptibility.

Original languageEnglish (US)
Pages (from-to)830-840.e4
JournalCell Host and Microbe
Volume27
Issue number5
DOIs
StatePublished - May 13 2020

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Virology

Keywords

  • immune variation
  • inflammatory bowel disease
  • machine learning model
  • multi-omic data integration
  • rewilded mice

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  • Cite this

    Lin, J. D., Devlin, J. C., Yeung, F., McCauley, C., Leung, J. M., Chen, Y. H., Cronkite, A., Hansen, C., Drake-Dunn, C., Ruggles, K. V., Cadwell, K., Graham, A. L., & Loke, P. (2020). Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition. Cell Host and Microbe, 27(5), 830-840.e4. https://doi.org/10.1016/j.chom.2020.03.001