TY - JOUR
T1 - Retrograde transport on the COG railway
AU - Ungar, Daniel
AU - Oka, Toshihiko
AU - Krieger, Monty
AU - Hughson, Frederick M.
PY - 2006/2
Y1 - 2006/2
N2 - The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.
AB - The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.
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U2 - 10.1016/j.tcb.2005.12.004
DO - 10.1016/j.tcb.2005.12.004
M3 - Review article
C2 - 16406524
AN - SCOPUS:32644472826
SN - 0962-8924
VL - 16
SP - 113
EP - 120
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -