Retrograde transport on the COG railway

Daniel Ungar, Toshihiko Oka, Monty Krieger, Frederick M. Hughson

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalTrends in Cell Biology
Volume16
Issue number2
DOIs
StatePublished - Feb 2006

All Science Journal Classification (ASJC) codes

  • Cell Biology

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