Responsive foams for nanoparticle delivery

Christina Tang, Edward Xiao, Patrick J. Sinko, Zoltan Szekely, Robert K. Prud'homme

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume133
DOIs
StatePublished - Sep 1 2015

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Keywords

  • Foams
  • Nanoparticle
  • Quick-break
  • Surfactant

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