Rescuing US biomedical research from its systemic flaws

Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, Harold Varmus

Research output: Contribution to journalReview articlepeer-review

538 Scopus citations


The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession - and making it difficult for seasoned investigators to produce their best work. This is a recipe for long-term decline, and the problems cannot be solved with simplistic approaches. Instead, it is time to confront the dangers at hand and rethink some fundamental features of the US biomedical research ecosystem.

Original languageEnglish (US)
Pages (from-to)5773-5777
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number16
StatePublished - Apr 22 2014

All Science Journal Classification (ASJC) codes

  • General


  • Federal funding
  • Graduate education
  • Peer review
  • Postdoctoral education


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