Representative subsampling of sedimenting blood

Bhargav Rallabandi, Janine K. Nunes, Antonio Perazzo, Sergey Gershtein, Howard A. Stone

Research output: Contribution to journalArticle

Abstract

It is often necessary to extract a small amount of a suspension, such as blood, from a larger sample of the same material for the purposes of diagnostics, testing or imaging. A practical challenge is that the cells in blood sediment noticeably on the time scale of a few minutes, making a representative subsampling of the original sample challenging. Guided by experimental data, we develop a Kynch sedimentation model to discuss design considerations that ensure a representative subsampling of blood, from a container of constant cross-sectional area, for the entire range of physiologically relevant hematocrit over a specified time of interest. Additionally, we show that this design may be modified to exploit the sedimentation and perform subsampling to achieve either higher or lower hematocrit relative to that of the original sample. Thus, our method provides a simple tool to either concentrate or dilute small quantities of blood or other sedimenting suspensions.

Original languageEnglish (US)
Article number2019.0223
JournalProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume475
Issue number2227
DOIs
StatePublished - Jul 1 2019

All Science Journal Classification (ASJC) codes

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Keywords

  • Blood
  • Complex fluids
  • Krieger-Dougherty
  • Kynch
  • Sedimentation

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