Abstract
A cDNA encoding the catalytic subunit of human telomerase was used to generate life-extended derivatives of primary human diploid fibroblasts. The life-extended cells supported efficient human cytomegalovirus (HCMV) replication. A subclone of the life-extended cells was generated containing the HCMV UL82 gene and used to isolate and propagate a virus that exhibited a profound growth defect after infection at a low input multiplicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10816-10818 |
| Number of pages | 3 |
| Journal | Journal of virology |
| Volume | 74 |
| Issue number | 22 |
| DOIs | |
| State | Published - 2000 |
All Science Journal Classification (ASJC) codes
- Insect Science
- Virology
- Microbiology
- Immunology
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