TY - JOUR
T1 - Remembrance of things past
T2 - Maintaining gene expression patterns with altered chromatin
AU - Hagstrom, Kirsten
AU - Schedl, Paul
PY - 1997/12
Y1 - 1997/12
N2 - Eukaryotic organisms have evolved mechanisms to stably preserve the gene expression patterns that determine cell fate. Recent advances have been made in understanding the DNA sequences and protein factors required to propagate gene activation or silencing. These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure.
AB - Eukaryotic organisms have evolved mechanisms to stably preserve the gene expression patterns that determine cell fate. Recent advances have been made in understanding the DNA sequences and protein factors required to propagate gene activation or silencing. These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031459641&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(97)80045-7
DO - 10.1016/S0959-437X(97)80045-7
M3 - Article
C2 - 9468792
AN - SCOPUS:0031459641
SN - 0959-437X
VL - 7
SP - 814
EP - 821
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 6
ER -