Remembrance of things past: Maintaining gene expression patterns with altered chromatin

Kirsten Hagstrom, Paul Daniel Schedl

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Eukaryotic organisms have evolved mechanisms to stably preserve the gene expression patterns that determine cell fate. Recent advances have been made in understanding the DNA sequences and protein factors required to propagate gene activation or silencing. These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure.

Original languageEnglish (US)
Pages (from-to)814-821
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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