Reiterated sequences within the intron of an immediate-early gene of herpes simplex virus type 1

Roger J. Watson; Kenichi Umene; Lynn W. Enquist

doi:10.1093/nar/9.16.4189

Reiterated sequences within the intron of an immediate-early gene of herpes simplex virus type 1

Roger J. Watson, Kenichi Umene, Lynn W. Enquist

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14 Scopus citations

Abstract

We describe the nucleotide sequence of a herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene. The location of the intron within this fragment was determined by a Berk & Sharp nuclease S1 protection analysis, and by cloning and sequencing cDNA containing sequences overlapping the IE mRNA-5 splice point. We found that the 149 base pair (bp) intron contained four copies of an identical 23 bp GC rich tandem repeat followed by a further reiteration consisting of the first 15 bp only.

Original language	English (US)
Pages (from-to)	4189-4199
Number of pages	11
Journal	Nucleic acids research
Volume	9
Issue number	16
DOIs	https://doi.org/10.1093/nar/9.16.4189
State	Published - Aug 25 1981

All Science Journal Classification (ASJC) codes

Genetics

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10.1093/nar/9.16.4189

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abstract = "We describe the nucleotide sequence of a herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene. The location of the intron within this fragment was determined by a Berk \& Sharp nuclease S1 protection analysis, and by cloning and sequencing cDNA containing sequences overlapping the IE mRNA-5 splice point. We found that the 149 base pair (bp) intron contained four copies of an identical 23 bp GC rich tandem repeat followed by a further reiteration consisting of the first 15 bp only.",

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AU - Umene, Kenichi

AU - Enquist, Lynn W.

PY - 1981/8/25

Y1 - 1981/8/25

N2 - We describe the nucleotide sequence of a herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene. The location of the intron within this fragment was determined by a Berk & Sharp nuclease S1 protection analysis, and by cloning and sequencing cDNA containing sequences overlapping the IE mRNA-5 splice point. We found that the 149 base pair (bp) intron contained four copies of an identical 23 bp GC rich tandem repeat followed by a further reiteration consisting of the first 15 bp only.

AB - We describe the nucleotide sequence of a herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene. The location of the intron within this fragment was determined by a Berk & Sharp nuclease S1 protection analysis, and by cloning and sequencing cDNA containing sequences overlapping the IE mRNA-5 splice point. We found that the 149 base pair (bp) intron contained four copies of an identical 23 bp GC rich tandem repeat followed by a further reiteration consisting of the first 15 bp only.

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JO - Nucleic acids research

JF - Nucleic acids research

IS - 16

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Reiterated sequences within the intron of an immediate-early gene of herpes simplex virus type 1

Abstract

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