Reiterated sequences within the intron of an immediate-early gene of herpes simplex virus type 1

Roger J. Watson, Kenichi Umene, Lynn W. Enquist

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We describe the nucleotide sequence of a herpes simplex virus type 1 DNA fragment containing the intron of the immediate-early mRNA-5 (IE mRNA-5) gene. The location of the intron within this fragment was determined by a Berk & Sharp nuclease S1 protection analysis, and by cloning and sequencing cDNA containing sequences overlapping the IE mRNA-5 splice point. We found that the 149 base pair (bp) intron contained four copies of an identical 23 bp GC rich tandem repeat followed by a further reiteration consisting of the first 15 bp only.

Original languageEnglish (US)
Pages (from-to)4189-4199
Number of pages11
JournalNucleic acids research
Volume9
Issue number16
DOIs
StatePublished - Aug 25 1981

All Science Journal Classification (ASJC) codes

  • Genetics

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