Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles

Boyuan Wang, Tom W. Muir

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

The agr locus encodes a quorum-sensing (QS) circuit required for the virulence of a spectrum of Gram-positive pathogens and is, therefore, regarded as an important target for the development of chemotherapeutics. In recent years, many of the biochemical events in the Staphylococcus aureus agr circuit have been reconstituted and subject to quantitative analysis in vitro. This work, in conjunction with structural studies on several key players in the signaling circuit, has furnished mechanistic insights into the regulation and evolution of the agr QS system. Here, we review this progress and discuss the remaining open questions in the area. We also highlight advances in the discovery of small-molecule agr modulators and how the newly available biochemical and structural information might be leveraged for the design of next-generation therapeutics targeting the agr system.

Original languageEnglish (US)
Pages (from-to)214-224
Number of pages11
JournalCell Chemical Biology
Volume23
Issue number2
DOIs
StatePublished - Feb 18 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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