Regulation of tissue morphodynamics: An important role for actomyosin contractility

Michael J. Siedlik, Celeste M. Nelson

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Forces arising from contractile actomyosin filaments help shape tissue form during morphogenesis. Developmental events that result from actomyosin contractility include tissue elongation, bending, budding, and collective migration. Here, we highlight recent insights into these morphogenetic processes from the perspective of actomyosin contractility as a key regulator. Emphasis is placed on a range of results obtained through live imaging, culture, and computational methods. Combining these approaches in the future has the potential to generate a robust, quantitative understanding of tissue morphodynamics.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalCurrent Opinion in Genetics and Development
StatePublished - Jun 1 2015

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


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