Regulation of reproduction and longevity by nutrient-sensing pathways

Nicole M. Templeman, Coleen T. Murphy

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


Nutrients are necessary for life, as they are a crucial requirement for biological processes including reproduction, somatic growth, and tissue maintenance. Therefore, signaling systems involved in detecting and interpreting nutrient or energy levels-most notably, the insulin/ insulin-like growth factor 1 (IGF-1) signaling pathway, mechanistic target of rapamycin (mTOR), and adenosine monophosphate-activated protein kinase (AMPK)-play important roles in regulating physiological decisions to reproduce, grow, and age. In this review, we discuss the connections between reproductive senescence and somatic aging and give an overview of the involvement of nutrient-sensing pathways in controlling both reproductive function and lifespan. Although the molecular mechanisms that affect these processes can be influenced by distinct tissue-, temporal-, and pathway-specific signaling events, the progression of reproductive aging and somatic aging is systemically coordinated by integrated nutrient- sensing signaling pathways regulating somatic tissue maintenance in conjunction with reproductive capacity.

Original languageEnglish (US)
Pages (from-to)93-106
Number of pages14
JournalJournal of Cell Biology
Issue number1
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Cell Biology


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