TY - JOUR
T1 - Regulation of reproduction and longevity by nutrient-sensing pathways
AU - Templeman, Nicole M.
AU - Murphy, Coleen T.
N1 - Funding Information:
C.T. Murphy is the Director of the Glenn Foundation for Aging Research at Princeton University and a Howard Hughes Medical Institute–Simons Foundation Faculty Scholar. This work was supported by a National Institutes of Health Director’s Pioneer Award (1DP1GM119167-01) to C.T. Murphy and a Canadian Institutes of Health Research Banting Postdoctoral Fellowship to N.M. Templeman. The authors declare no competing financial interests.
Funding Information:
C.T. Murphy is the Director of the Glenn Foundation for Aging Research at Princeton University and a Howard Hughes Medical Institute-Simons Foundation Faculty Scholar. This work was supported by a National Institutes of Health Director's Pioneer Award (1DP1GM119167-01) to C.T. Murphy and a Canadian Institutes of Health Research Banting Postdoctoral Fellowship to N.M. Templeman. The authors declare no competing financial interests.
Publisher Copyright:
© 2018 Templeman and Murphy.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Nutrients are necessary for life, as they are a crucial requirement for biological processes including reproduction, somatic growth, and tissue maintenance. Therefore, signaling systems involved in detecting and interpreting nutrient or energy levels-most notably, the insulin/ insulin-like growth factor 1 (IGF-1) signaling pathway, mechanistic target of rapamycin (mTOR), and adenosine monophosphate-activated protein kinase (AMPK)-play important roles in regulating physiological decisions to reproduce, grow, and age. In this review, we discuss the connections between reproductive senescence and somatic aging and give an overview of the involvement of nutrient-sensing pathways in controlling both reproductive function and lifespan. Although the molecular mechanisms that affect these processes can be influenced by distinct tissue-, temporal-, and pathway-specific signaling events, the progression of reproductive aging and somatic aging is systemically coordinated by integrated nutrient- sensing signaling pathways regulating somatic tissue maintenance in conjunction with reproductive capacity.
AB - Nutrients are necessary for life, as they are a crucial requirement for biological processes including reproduction, somatic growth, and tissue maintenance. Therefore, signaling systems involved in detecting and interpreting nutrient or energy levels-most notably, the insulin/ insulin-like growth factor 1 (IGF-1) signaling pathway, mechanistic target of rapamycin (mTOR), and adenosine monophosphate-activated protein kinase (AMPK)-play important roles in regulating physiological decisions to reproduce, grow, and age. In this review, we discuss the connections between reproductive senescence and somatic aging and give an overview of the involvement of nutrient-sensing pathways in controlling both reproductive function and lifespan. Although the molecular mechanisms that affect these processes can be influenced by distinct tissue-, temporal-, and pathway-specific signaling events, the progression of reproductive aging and somatic aging is systemically coordinated by integrated nutrient- sensing signaling pathways regulating somatic tissue maintenance in conjunction with reproductive capacity.
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U2 - 10.1083/jcb.201707168
DO - 10.1083/jcb.201707168
M3 - Review article
C2 - 29074705
AN - SCOPUS:85039850736
SN - 0021-9525
VL - 217
SP - 93
EP - 106
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 1
ER -