TY - JOUR
T1 - Regulation of Energy Expenditure by Brainstem GABA Neurons
AU - Schneeberger, Marc
AU - Parolari, Luca
AU - Das Banerjee, Tania
AU - Bhave, Varun
AU - Wang, Putianqi
AU - Patel, Bindiben
AU - Topilko, Thomas
AU - Wu, Zhuhao
AU - Choi, Chan Hee J.
AU - Yu, Xiaofei
AU - Pellegrino, Kyle
AU - Engel, Esteban A.
AU - Cohen, Paul
AU - Renier, Nicolas
AU - Friedman, Jeffrey M.
AU - Nectow, Alexander R.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/7/25
Y1 - 2019/7/25
N2 - Homeostatic control of core body temperature is essential for survival. Temperature is sensed by specific neurons, in turn eliciting both behavioral (i.e., locomotion) and physiologic (i.e., thermogenesis, vasodilatation) responses. Here, we report that a population of GABAergic (Vgat-expressing) neurons in the dorsolateral portion of the dorsal raphe nucleus (DRN), hereafter DRNVgat neurons, are activated by ambient heat and bidirectionally regulate energy expenditure through changes in both thermogenesis and locomotion. We find that DRNVgat neurons innervate brown fat via a descending projection to the raphe pallidus (RPa). These neurons also densely innervate ascending targets implicated in the central regulation of energy expenditure, including the hypothalamus and extended amygdala. Optogenetic stimulation of different projection targets reveals that DRNVgat neurons are capable of regulating thermogenesis through both a “direct” descending pathway through the RPa and multiple “indirect” ascending pathways. This work establishes a key regulatory role for DRNVgat neurons in controlling energy expenditure.
AB - Homeostatic control of core body temperature is essential for survival. Temperature is sensed by specific neurons, in turn eliciting both behavioral (i.e., locomotion) and physiologic (i.e., thermogenesis, vasodilatation) responses. Here, we report that a population of GABAergic (Vgat-expressing) neurons in the dorsolateral portion of the dorsal raphe nucleus (DRN), hereafter DRNVgat neurons, are activated by ambient heat and bidirectionally regulate energy expenditure through changes in both thermogenesis and locomotion. We find that DRNVgat neurons innervate brown fat via a descending projection to the raphe pallidus (RPa). These neurons also densely innervate ascending targets implicated in the central regulation of energy expenditure, including the hypothalamus and extended amygdala. Optogenetic stimulation of different projection targets reveals that DRNVgat neurons are capable of regulating thermogenesis through both a “direct” descending pathway through the RPa and multiple “indirect” ascending pathways. This work establishes a key regulatory role for DRNVgat neurons in controlling energy expenditure.
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U2 - 10.1016/j.cell.2019.05.048
DO - 10.1016/j.cell.2019.05.048
M3 - Article
C2 - 31257028
AN - SCOPUS:85069047594
SN - 0092-8674
VL - 178
SP - 672-685.e12
JO - Cell
JF - Cell
IS - 3
ER -