Reduced model-based decision-making in gambling disorder

Florent Wyckmans, A. Ross Otto, Miriam Sebold, Nathaniel Daw, Antoine Bechara, Mélanie Saeremans, Charles Kornreich, Armand Chatard, Nemat Jaafari, Xavier Noël

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Compulsive behaviors (e.g., addiction) can be viewed as an aberrant decision process where inflexible reactions automatically evoked by stimuli (habit) take control over decision making to the detriment of a more flexible (goal-oriented) behavioral learning system. These behaviors are thought to arise from learning algorithms known as “model-based” and “model-free” reinforcement learning. Gambling disorder, a form of addiction without the confound of neurotoxic effects of drugs, showed impaired goal-directed control but the way in which problem gamblers (PG) orchestrate model-based and model-free strategies has not been evaluated. Forty-nine PG and 33 healthy participants (CP) completed a two-step sequential choice task for which model-based and model-free learning have distinct and identifiable trial-by-trial learning signatures. The influence of common psychopathological comorbidities on those two forms of learning were investigated. PG showed impaired model-based learning, particularly after unrewarded outcomes. In addition, PG exhibited faster reaction times than CP following unrewarded decisions. Troubled mood, higher impulsivity (i.e., positive and negative urgency) and current and chronic stress reported via questionnaires did not account for those results. These findings demonstrate specific reinforcement learning and decision-making deficits in behavioral addiction that advances our understanding and may be important dimensions for designing effective interventions.

Original languageEnglish (US)
Article number19625
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Reduced model-based decision-making in gambling disorder'. Together they form a unique fingerprint.

  • Cite this

    Wyckmans, F., Otto, A. R., Sebold, M., Daw, N., Bechara, A., Saeremans, M., Kornreich, C., Chatard, A., Jaafari, N., & Noël, X. (2019). Reduced model-based decision-making in gambling disorder. Scientific reports, 9(1), [19625]. https://doi.org/10.1038/s41598-019-56161-z