@article{6e7b6cda8c8e451fadda737fd950d971,
title = "Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization",
abstract = "C(sp3)-rich aliphatic motifs in drug molecules are strongly associated with clinical success. Historically, the availability of compound libraries based on C(sp3)-rich cores has been limited due to the challenging direct functionalization of aliphatic rings. Instead, most small molecule drug-like libraries are diversified around central aromatic rings. Herein, we present a general approach to the synthesis of diversified libraries featuring aliphatic core rings via photoredox catalysis under mild conditions.",
author = "Fern{\'a}ndez, {David F.} and Mar{\'i}a Gonz{\'a}lez-Esguevillas and Sebastian Keess and Felix Sch{\"a}fer and Jens Mohr and Andre Shavnya and Thomas Knauber and Blakemore, {David C.} and MacMillan, {David W.C.}",
note = "Funding Information: The authors are grateful for financial support from Xunta de Galicia (ED481B-2019-005), Deutsche Forschungsgemeinschaft (KE 2388/3-1, MO 3233/1-1, and MO 3233/1-2), and DAAD. The authors are thankful for the support provided by the National Institute of General Medical Sciences (NIGMS), the National Institutes of Health (under Award R35GM134897-03), and the Princeton Catalysis Initiative. The authors thank Dr. Phil Jeffrey (Princeton University, Princeton, NJ) for crystal structure determination. Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",
year = "2023",
doi = "10.1021/acs.orglett.3c00994",
language = "English (US)",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
}