Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

Nathalie M. Pinkerton, Céline Frongia, Valérie Lobjois, Brian K. Wilson, Matthew J. Bruzek, Robert K. Prud'Homme, John Anthony, Frédéric Bolze, Stefan Chassaing

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Biocompatible and biostable EtTP-5-loaded organic core-shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.

Original languageEnglish (US)
Pages (from-to)65770-65774
Number of pages5
JournalRSC Advances
Volume6
Issue number70
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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    Pinkerton, N. M., Frongia, C., Lobjois, V., Wilson, B. K., Bruzek, M. J., Prud'Homme, R. K., Anthony, J., Bolze, F., & Chassaing, S. (2016). Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models. RSC Advances, 6(70), 65770-65774. https://doi.org/10.1039/c6ra09954h