56 Scopus citations

Abstract

The mechanisms of red blood cell (RBC) deformation under both static and dynamic, i.e., flow, conditions have been studied extensively since the mid 1960s. Deformation-induced biochemical reactions and possible signaling in RBCs, however, were proposed only fifteen years ago. Therefore, the fundamental relationship between RBC deformation and cellular signaling dynamics i.e., mechanotransduction, remains incompletely understood. Quantitative understanding of the mechanotransductive pathways in RBCs requires integrative studies of physical models of RBC deformation and cellular biochemical reactions. In this article we review the physical models of RBC deformation, spanning from continuum membrane mechanics to cellular skeleton dynamics under both static and flow conditions, and elaborate the mechanistic links involved in deformation-induced ATP release.

Original languageEnglish (US)
Pages (from-to)972-981
Number of pages10
JournalIntegrative Biology
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2011

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

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