Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

Alfredo M. Valencia; Clayton K. Collings; Hai T. Dao; Roodolph St. Pierre; Yung Chih Cheng; Junwei Huang; Zhen Yu Sun; Hyuk Soo Seo; Nazar Mashtalir; Dawn E. Comstock; Olubusayo Bolonduro; Nicholas E. Vangos; Zoe C. Yeoh; Mary Kate Dornon; Crystal Hermawan; Lee Barrett; Sirano Dhe-Paganon; Clifford J. Woolf; Tom W. Muir; Cigall Kadoch

doi:10.1016/j.cell.2019.10.044

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

Alfredo M. Valencia
, Clayton K. Collings
, Hai T. Dao
, Roodolph St. Pierre
, Yung Chih Cheng
, Junwei Huang
, Zhen Yu Sun
, Hyuk Soo Seo
, Nazar Mashtalir
, Dawn E. Comstock
, Olubusayo Bolonduro
, Nicholas E. Vangos
, Zoe C. Yeoh
, Mary Kate Dornon
, Crystal Hermawan
, Lee Barrett
, Sirano Dhe-Paganon
, Clifford J. Woolf
, Tom W. Muir
, Cigall Kadoch

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

The SMARCB1 C-terminal alpha-helical domain binds the nucleosome acidic patch and mediates mSWI/SNF chromatin remodeling.

Original language	English (US)
Pages (from-to)	1342-1356.e23
Journal	Cell
Volume	179
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2019.10.044
State	Published - Nov 27 2019

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Keywords

ATP-dependent chromatin remodeling
BAF complex
Coffin-Siris syndrome
SMARCB1 (BAF47)
chromatin accessibility
intellectual disability
mammalian SWI/SNF complexes
nucleosome acidic patch
nucleosome remodeling
structure

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10.1016/j.cell.2019.10.044

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Valencia, A. M., Collings, C. K., Dao, H. T., St. Pierre, R., Cheng, Y. C., Huang, J., Sun, Z. Y., Seo, H. S., Mashtalir, N., Comstock, D. E., Bolonduro, O., Vangos, N. E., Yeoh, Z. C., Dornon, M. K., Hermawan, C., Barrett, L., Dhe-Paganon, S., Woolf, C. J., Muir, T. W., & Kadoch, C. (2019). Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell, 179(6), 1342-1356.e23. https://doi.org/10.1016/j.cell.2019.10.044

@article{bab07417570d453a92a836b0c8adba12,

title = "Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling",

abstract = "The SMARCB1 C-terminal alpha-helical domain binds the nucleosome acidic patch and mediates mSWI/SNF chromatin remodeling.",

keywords = "ATP-dependent chromatin remodeling, BAF complex, Coffin-Siris syndrome, SMARCB1 (BAF47), chromatin accessibility, intellectual disability, mammalian SWI/SNF complexes, nucleosome acidic patch, nucleosome remodeling, structure",

author = "Valencia, \{Alfredo M.\} and Collings, \{Clayton K.\} and Dao, \{Hai T.\} and \{St. Pierre\}, Roodolph and Cheng, \{Yung Chih\} and Junwei Huang and Sun, \{Zhen Yu\} and Seo, \{Hyuk Soo\} and Nazar Mashtalir and Comstock, \{Dawn E.\} and Olubusayo Bolonduro and Vangos, \{Nicholas E.\} and Yeoh, \{Zoe C.\} and Dornon, \{Mary Kate\} and Crystal Hermawan and Lee Barrett and Sirano Dhe-Paganon and Woolf, \{Clifford J.\} and Muir, \{Tom W.\} and Cigall Kadoch",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

day = "27",

doi = "10.1016/j.cell.2019.10.044",

language = "English (US)",

volume = "179",

pages = "1342--1356.e23",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "6",

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Valencia, AM, Collings, CK, Dao, HT, St. Pierre, R, Cheng, YC, Huang, J, Sun, ZY, Seo, HS, Mashtalir, N, Comstock, DE, Bolonduro, O, Vangos, NE, Yeoh, ZC, Dornon, MK, Hermawan, C, Barrett, L, Dhe-Paganon, S, Woolf, CJ, Muir, TW & Kadoch, C 2019, 'Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling', Cell, vol. 179, no. 6, pp. 1342-1356.e23. https://doi.org/10.1016/j.cell.2019.10.044

TY - JOUR

T1 - Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

AU - Valencia, Alfredo M.

AU - Collings, Clayton K.

AU - Dao, Hai T.

AU - St. Pierre, Roodolph

AU - Cheng, Yung Chih

AU - Huang, Junwei

AU - Sun, Zhen Yu

AU - Seo, Hyuk Soo

AU - Mashtalir, Nazar

AU - Comstock, Dawn E.

AU - Bolonduro, Olubusayo

AU - Vangos, Nicholas E.

AU - Yeoh, Zoe C.

AU - Dornon, Mary Kate

AU - Hermawan, Crystal

AU - Barrett, Lee

AU - Dhe-Paganon, Sirano

AU - Woolf, Clifford J.

AU - Muir, Tom W.

AU - Kadoch, Cigall

PY - 2019/11/27

Y1 - 2019/11/27

N2 - The SMARCB1 C-terminal alpha-helical domain binds the nucleosome acidic patch and mediates mSWI/SNF chromatin remodeling.

AB - The SMARCB1 C-terminal alpha-helical domain binds the nucleosome acidic patch and mediates mSWI/SNF chromatin remodeling.

KW - ATP-dependent chromatin remodeling

KW - BAF complex

KW - Coffin-Siris syndrome

KW - SMARCB1 (BAF47)

KW - chromatin accessibility

KW - intellectual disability

KW - mammalian SWI/SNF complexes

KW - nucleosome acidic patch

KW - nucleosome remodeling

KW - structure

UR - https://www.scopus.com/pages/publications/85075534826

UR - https://www.scopus.com/pages/publications/85075534826#tab=citedBy

U2 - 10.1016/j.cell.2019.10.044

DO - 10.1016/j.cell.2019.10.044

M3 - Article

C2 - 31759698

AN - SCOPUS:85075534826

SN - 0092-8674

VL - 179

SP - 1342-1356.e23

JO - Cell

JF - Cell

IS - 6

ER -

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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