Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

Alfredo M. Valencia, Clayton K. Collings, Hai T. Dao, Roodolph St. Pierre, Yung Chih Cheng, Junwei Huang, Zhen Yu Sun, Hyuk Soo Seo, Nazar Mashtalir, Dawn E. Comstock, Olubusayo Bolonduro, Nicholas E. Vangos, Zoe C. Yeoh, Mary Kate Dornon, Crystal Hermawan, Lee Barrett, Sirano Dhe-Paganon, Clifford J. Woolf, Tom W. Muir, Cigall Kadoch

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The SMARCB1 C-terminal alpha-helical domain binds the nucleosome acidic patch and mediates mSWI/SNF chromatin remodeling.

Original languageEnglish (US)
Pages (from-to)1342-1356.e23
JournalCell
Volume179
Issue number6
DOIs
StatePublished - Nov 27 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • ATP-dependent chromatin remodeling
  • BAF complex
  • Coffin-Siris syndrome
  • SMARCB1 (BAF47)
  • chromatin accessibility
  • intellectual disability
  • mammalian SWI/SNF complexes
  • nucleosome acidic patch
  • nucleosome remodeling
  • structure

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