Recent developments in the computational simulation of dry powder inhalers

Jesse Capecelatro, Worth Longest, Connor Boerman, Mostafa Sulaiman, Sankaran Sundaresan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

This article reviews recent developments in computational modeling of dry powder inhalers (DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a patient's lungs via inhalation. Inhaler design is complicated by the need for maximum aerosolization efficiency, which is favored by high levels of turbulence near the mouthpiece, with low extrathoracic depositional loss, which requires low turbulence levels near the mouth-throat region. In this article, we review the physical processes contributing to aerosolization and subsequent dispersion and deposition. We assess the performance characteristics of DPIs using existing simulation techniques and offer a perspective on how such simulations can be improved to capture the physical processes occurring over a wide range of length- and timescales more efficiently.

Original languageEnglish (US)
Article number114461
JournalAdvanced Drug Delivery Reviews
Volume188
DOIs
StatePublished - Sep 2022

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Aerosolization
  • CFD–DEM
  • Dispersion
  • Dry powder inhaler
  • Pulmonary drug administration

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