TY - JOUR
T1 - Recent advances in understanding hepatitis C
AU - Ploss, Alexander
AU - Douam, Florian
AU - Ding, Qiang
N1 - Funding Information:
Work in the laboratory is supported in part by grants from the National Institutes of Health (1R21AI117213, 2R01 AI079031, 1 R01 AI107301, 1 R56 AI106005) and a Research Scholar Award (to AP) from the American Cancer Society (RSG-15-048-01-MPC). QD is a recipient of a postdoctoral fellowship from the New Jersey Commission for Cancer Research (DHFS16PPC007). We apologize to all colleagues whose work could not be cited because of space constraints.
Publisher Copyright:
© 2016 Douam F et al.
PY - 2016
Y1 - 2016
N2 - The past decade has seen tremendous progress in understanding hepatitis C virus (HCV) biology and its related disease, hepatitis C. Major advances in characterizing viral replication have led to the development of direct-acting anti-viral therapies that have considerably improved patient treatment outcome and can even cure chronic infection. However, the high cost of these treatments, their low barrier to viral resistance, and their inability to prevent HCV-induced liver cancer, along with the absence of an effective HCV vaccine, all underscore the need for continued efforts to understand the biology of this virus. Moreover, beyond informing therapies, enhanced knowledge of HCV biology is itself extremely valuable for understanding the biology of related viruses, such as dengue virus, which is becoming a growing global health concern. Major advances have been realized over the last few years in HCV biology and pathogenesis, such as the discovery of the envelope glycoprotein E2 core structure, the generation of the first mouse model with inheritable susceptibility to HCV, and the characterization of virus-host interactions that regulate viral replication or innate immunity. Here, we review the recent findings that have significantly advanced our understanding of HCV and highlight the major challenges that remain.
AB - The past decade has seen tremendous progress in understanding hepatitis C virus (HCV) biology and its related disease, hepatitis C. Major advances in characterizing viral replication have led to the development of direct-acting anti-viral therapies that have considerably improved patient treatment outcome and can even cure chronic infection. However, the high cost of these treatments, their low barrier to viral resistance, and their inability to prevent HCV-induced liver cancer, along with the absence of an effective HCV vaccine, all underscore the need for continued efforts to understand the biology of this virus. Moreover, beyond informing therapies, enhanced knowledge of HCV biology is itself extremely valuable for understanding the biology of related viruses, such as dengue virus, which is becoming a growing global health concern. Major advances have been realized over the last few years in HCV biology and pathogenesis, such as the discovery of the envelope glycoprotein E2 core structure, the generation of the first mouse model with inheritable susceptibility to HCV, and the characterization of virus-host interactions that regulate viral replication or innate immunity. Here, we review the recent findings that have significantly advanced our understanding of HCV and highlight the major challenges that remain.
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U2 - 10.12688/f1000research.7354.1
DO - 10.12688/f1000research.7354.1
M3 - Review article
C2 - 26918166
AN - SCOPUS:84964526841
SN - 2046-1402
VL - 5
JO - F1000Research
JF - F1000Research
M1 - 131
ER -