Rapid expansion of supercritical solutions (RESS): Fundamentals and applications

P. G. Debenedetti; J. W. Tom; X. Kwauk; S. D. Yeo

doi:10.1016/0378-3812(93)87156-U

Rapid expansion of supercritical solutions (RESS): Fundamentals and applications

P. G. Debenedetti, J. W. Tom, X. Kwauk, S. D. Yeo

Research output: Contribution to journal › Conference article › peer-review

122 Scopus citations

Abstract

The rapid expansion of supercritical solutions is a promising new technology for particle formation. The absence of liquid organic solvents, the mild processing temperatures, and the purity of the final product make this process particularly attractive for biomedical applications. In our laboratory, the technique has been used to produce bioerodible polymeric microspheres loaded with a therapeutic drug, a composite suitable for controlled delivery applications. The mathematical modelling of nucleation and growth during the expansion process is useful both in the interpretation of experimental observations, and as a guide for the identification of process conditions leading to unimodal particle size distributions.

Original language	English (US)
Pages (from-to)	311-321
Number of pages	11
Journal	Fluid Phase Equilibria
Volume	82
Issue number	pt 1
DOIs	https://doi.org/10.1016/0378-3812(93)87156-U
State	Published - 1993
Event	Proceedings of the 6th International Conference on Fluid Properties and Phase Equilibria for Chemical Process Design 1992 - Cortina d'Ampezzo, Italy Duration: Jul 19 1992 → Jul 24 1992

All Science Journal Classification (ASJC) codes

General Chemical Engineering
General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1016/0378-3812(93)87156-U

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title = "Rapid expansion of supercritical solutions (RESS): Fundamentals and applications",

abstract = "The rapid expansion of supercritical solutions is a promising new technology for particle formation. The absence of liquid organic solvents, the mild processing temperatures, and the purity of the final product make this process particularly attractive for biomedical applications. In our laboratory, the technique has been used to produce bioerodible polymeric microspheres loaded with a therapeutic drug, a composite suitable for controlled delivery applications. The mathematical modelling of nucleation and growth during the expansion process is useful both in the interpretation of experimental observations, and as a guide for the identification of process conditions leading to unimodal particle size distributions.",

author = "Debenedetti, {P. G.} and Tom, {J. W.} and X. Kwauk and Yeo, {S. D.}",

note = "Funding Information: PGD gratefully acknowledges the support of the National Science Foundation (Grant CTS-9000614); the Camille and Henry Dreyfus Foundation (1989 Teacher-Scholar Award); the John Simon Guggenheim Memorial Foundation (1991; Proceedings of the 6th International Conference on Fluid Properties and Phase Equilibria for Chemical Process Design 1992 ; Conference date: 19-07-1992 Through 24-07-1992",

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T2 - Proceedings of the 6th International Conference on Fluid Properties and Phase Equilibria for Chemical Process Design 1992

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AU - Tom, J. W.

AU - Kwauk, X.

AU - Yeo, S. D.

N1 - Funding Information: PGD gratefully acknowledges the support of the National Science Foundation (Grant CTS-9000614); the Camille and Henry Dreyfus Foundation (1989 Teacher-Scholar Award); the John Simon Guggenheim Memorial Foundation (1991

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Y1 - 1993

N2 - The rapid expansion of supercritical solutions is a promising new technology for particle formation. The absence of liquid organic solvents, the mild processing temperatures, and the purity of the final product make this process particularly attractive for biomedical applications. In our laboratory, the technique has been used to produce bioerodible polymeric microspheres loaded with a therapeutic drug, a composite suitable for controlled delivery applications. The mathematical modelling of nucleation and growth during the expansion process is useful both in the interpretation of experimental observations, and as a guide for the identification of process conditions leading to unimodal particle size distributions.

AB - The rapid expansion of supercritical solutions is a promising new technology for particle formation. The absence of liquid organic solvents, the mild processing temperatures, and the purity of the final product make this process particularly attractive for biomedical applications. In our laboratory, the technique has been used to produce bioerodible polymeric microspheres loaded with a therapeutic drug, a composite suitable for controlled delivery applications. The mathematical modelling of nucleation and growth during the expansion process is useful both in the interpretation of experimental observations, and as a guide for the identification of process conditions leading to unimodal particle size distributions.

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Rapid expansion of supercritical solutions (RESS): Fundamentals and applications

Abstract

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