Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Shannon E. Keenan; Shelby A. Blythe; Robert A. Marmion; Nareg J.V. Djabrayan; Eric F. Wieschaus; Stanislav Y. Shvartsman

doi:10.1016/j.devcel.2020.02.004

Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Shannon E. Keenan
, Shelby A. Blythe
, Robert A. Marmion
, Nareg J.V. Djabrayan
, Eric F. Wieschaus
, Stanislav Y. Shvartsman

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.

Original language	English (US)
Pages (from-to)	794-801.e4
Journal	Developmental cell
Volume	52
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2020.02.004
State	Published - Mar 23 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Keywords

Capicua
Drosophila
ERK
cellular signaling
development
optogenetics
transcriptional repression

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10.1016/j.devcel.2020.02.004

Cite this

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title = "Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua",

abstract = "Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.",

keywords = "Capicua, Drosophila, ERK, cellular signaling, development, optogenetics, transcriptional repression",

author = "Keenan, \{Shannon E.\} and Blythe, \{Shelby A.\} and Marmion, \{Robert A.\} and Djabrayan, \{Nareg J.V.\} and Wieschaus, \{Eric F.\} and Shvartsman, \{Stanislav Y.\}",

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year = "2020",

month = mar,

day = "23",

doi = "10.1016/j.devcel.2020.02.004",

language = "English (US)",

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T1 - Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

AU - Keenan, Shannon E.

AU - Blythe, Shelby A.

AU - Marmion, Robert A.

AU - Djabrayan, Nareg J.V.

AU - Wieschaus, Eric F.

AU - Shvartsman, Stanislav Y.

PY - 2020/3/23

Y1 - 2020/3/23

N2 - Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.

AB - Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.

KW - Capicua

KW - Drosophila

KW - ERK

KW - cellular signaling

KW - development

KW - optogenetics

KW - transcriptional repression

UR - https://www.scopus.com/pages/publications/85081700726

UR - https://www.scopus.com/pages/publications/85081700726#tab=citedBy

U2 - 10.1016/j.devcel.2020.02.004

DO - 10.1016/j.devcel.2020.02.004

M3 - Article

C2 - 32142631

AN - SCOPUS:85081700726

SN - 1534-5807

VL - 52

SP - 794-801.e4

JO - Developmental cell

JF - Developmental cell

IS - 6

ER -

Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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