Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology
- cellular signaling
- transcriptional repression