Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Shannon E. Keenan, Shelby A. Blythe, Robert A. Marmion, Nareg J.V. Djabrayan, Eric F. Wieschaus, Stanislav Y. Shvartsman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.

Original languageEnglish (US)
Pages (from-to)794-801.e4
JournalDevelopmental cell
Issue number6
StatePublished - Mar 23 2020

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


  • Capicua
  • Drosophila
  • ERK
  • cellular signaling
  • development
  • optogenetics
  • transcriptional repression


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