Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples

Lee Jinbo, Julianne A. Hunt, John Taylor Groves

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Mn(III)TMPyP reacts rapidly with the toxic oxidant peroxynitrite (ONOO- ) to generate an oxoMn(IV) species, but Mn(III)TMPyP is not catalytic for ONOO- decomposition due to the slow reduction of oxoMn(IV) back to the Mn(III) oxidation state. However, when redox-coupled with biological antioxidants that efficiently reduce oxoMn(IV), Mn(III)TMPyP is transformed into an efficient 'peroxynitrite reductase'.

Original languageEnglish (US)
Pages (from-to)2913-2918
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number22
DOIs
StatePublished - Nov 18 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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