Raphe neurons: Firing rate correlates with size of drug response

Barry L. Jacobs, James Heym, Kurt Rasmussen

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Significant negative correlations were obtained between the spontaneous discharge rate during waking and the neural response to systemic injections of either 5-MeODMT or LSD for serotonergic neurons in the dorsal raphe nucleus, nucleus centralis superior, and nucleus raphe pallidus of unanesthetized and unrestrained cats. These data are discussed in terms of an hypothesis which accounts for both the rate of spontaneous activity of serotonergic neurons and the magnitude of their response to serotonin agonist drugs in terms of autoreceptor density on individual neurons.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - Jun 3 1983

All Science Journal Classification (ASJC) codes

  • Pharmacology


  • Autoreceptors
  • Freely moving cats
  • Raphe nuclei
  • Serotonin
  • Single unit activity


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