RAI2: Linking retinoic acid signaling with metastasis suppression

Mark Esposito, Yibin Kang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Considerable evidence points to the importance of disseminated tumor cells, which are commonly detected in the bone marrow and display features of cellular plasticity, in predicting the clinical outcome of breast cancer. In this issue of Cancer Discovery, Werner and colleagues report on the discovery of retinoic acid–induced 2 (RAI2) as a differentiation factor that suppresses early metastatic spread of estrogen receptor–positive breast cancer.

Original languageEnglish (US)
Pages (from-to)466-468
Number of pages3
JournalCancer Discovery
Issue number5
StatePublished - May 2015

All Science Journal Classification (ASJC) codes

  • Oncology


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