Radical alkylation of N-alkyl 1,2,4-triazoles

Karl B. Hansen; Shawn A. Springfield; Richard Desmond; Paul N. Devine; Edward J.J. Grabowski; Paul J. Reider

doi:10.1016/S0040-4039(01)01518-0

Radical alkylation of N-alkyl 1,2,4-triazoles

Karl B. Hansen, Shawn A. Springfield, Richard Desmond, Paul N. Devine, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion.

Original language	English (US)
Pages (from-to)	7353-7355
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(01)01518-0
State	Published - Oct 15 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01518-0

Cite this

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title = "Radical alkylation of N-alkyl 1,2,4-triazoles",

abstract = "Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion.",

author = "Hansen, \{Karl B.\} and Springfield, \{Shawn A.\} and Richard Desmond and Devine, \{Paul N.\} and Grabowski, \{Edward J.J.\} and Reider, \{Paul J.\}",

year = "2001",

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day = "15",

doi = "10.1016/S0040-4039(01)01518-0",

language = "English (US)",

volume = "42",

pages = "7353--7355",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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T1 - Radical alkylation of N-alkyl 1,2,4-triazoles

AU - Hansen, Karl B.

AU - Springfield, Shawn A.

AU - Desmond, Richard

AU - Devine, Paul N.

AU - Grabowski, Edward J.J.

AU - Reider, Paul J.

PY - 2001/10/15

Y1 - 2001/10/15

N2 - Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion.

AB - Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion.

UR - https://www.scopus.com/pages/publications/0035888148

UR - https://www.scopus.com/inward/citedby.url?scp=0035888148&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)01518-0

DO - 10.1016/S0040-4039(01)01518-0

M3 - Article

AN - SCOPUS:0035888148

SN - 0040-4039

VL - 42

SP - 7353

EP - 7355

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Radical alkylation of N-alkyl 1,2,4-triazoles

Abstract

All Science Journal Classification (ASJC) codes

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