Radical alkylation of N-alkyl 1,2,4-triazoles

Karl B. Hansen, Shawn A. Springfield, Richard Desmond, Paul N. Devine, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion.

Original languageEnglish (US)
Pages (from-to)7353-7355
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number42
DOIs
StatePublished - Oct 15 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Hansen, K. B., Springfield, S. A., Desmond, R., Devine, P. N., Grabowski, E. J. J., & Reider, P. J. (2001). Radical alkylation of N-alkyl 1,2,4-triazoles. Tetrahedron Letters, 42(42), 7353-7355. https://doi.org/10.1016/S0040-4039(01)01518-0