Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry