A novel enzymatic resolution of ortho-substituted 2-arylpropanoic acids using rabbit liver esterase is described. The R-enantiomer is obtained by enzymatic hydrolysis of the ethyl ester whereas the S-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding methyl esters.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 29 1992|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry