Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids

Chris H. Senanayake, Timothy J. Bill, Robert D. Larsen, John Leazer, Paul J. Reider

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A novel enzymatic resolution of ortho-substituted 2-arylpropanoic acids using rabbit liver esterase is described. The R-enantiomer is obtained by enzymatic hydrolysis of the ethyl ester whereas the S-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding methyl esters.

Original languageEnglish (US)
Pages (from-to)5901-5904
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number40
DOIs
StatePublished - Sep 29 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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