Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids

Chris H. Senanayake; Timothy J. Bill; Robert D. Larsen; John Leazer; Paul J. Reider

doi:10.1016/S0040-4039(00)61084-5

Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids

Chris H. Senanayake, Timothy J. Bill, Robert D. Larsen, John Leazer, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A novel enzymatic resolution of ortho-substituted 2-arylpropanoic acids using rabbit liver esterase is described. The R-enantiomer is obtained by enzymatic hydrolysis of the ethyl ester whereas the S-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding methyl esters.

Original language	English (US)
Pages (from-to)	5901-5904
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	40
DOIs	https://doi.org/10.1016/S0040-4039(00)61084-5
State	Published - Sep 29 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)61084-5

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title = "Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids",

abstract = "A novel enzymatic resolution of ortho-substituted 2-arylpropanoic acids using rabbit liver esterase is described. The R-enantiomer is obtained by enzymatic hydrolysis of the ethyl ester whereas the S-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding methyl esters.",

author = "Senanayake, {Chris H.} and Bill, {Timothy J.} and Larsen, {Robert D.} and John Leazer and Reider, {Paul J.}",

year = "1992",

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T1 - Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids

AU - Senanayake, Chris H.

AU - Bill, Timothy J.

AU - Larsen, Robert D.

AU - Leazer, John

AU - Reider, Paul J.

PY - 1992/9/29

Y1 - 1992/9/29

N2 - A novel enzymatic resolution of ortho-substituted 2-arylpropanoic acids using rabbit liver esterase is described. The R-enantiomer is obtained by enzymatic hydrolysis of the ethyl ester whereas the S-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding methyl esters.

AB - A novel enzymatic resolution of ortho-substituted 2-arylpropanoic acids using rabbit liver esterase is described. The R-enantiomer is obtained by enzymatic hydrolysis of the ethyl ester whereas the S-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding methyl esters.

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DO - 10.1016/S0040-4039(00)61084-5

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids

Abstract

All Science Journal Classification (ASJC) codes

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