TY - JOUR
T1 - Quorum sensing signal-response systems in Gram-negative bacteria
AU - Papenfort, Kai
AU - Bassler, Bonnie Lynn
N1 - Publisher Copyright:
© 2016 Macmillan Publishers Limited, part of Springer Nature.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Bacteria use quorum sensing to orchestrate gene expression programmes that underlie collective behaviours. Quorum sensing relies on the production, release, detection and group-level response to extracellular signalling molecules, which are called autoinducers. Recent work has discovered new autoinducers in Gram-negative bacteria, shown how these molecules are recognized by cognate receptors, revealed new regulatory components that are embedded in canonical signalling circuits and identified novel regulatory network designs. In this Review we examine how, together, these features of quorum sensing signal-response systems combine to control collective behaviours in Gram-negative bacteria and we discuss the implications for host-microbial associations and antibacterial therapy.
AB - Bacteria use quorum sensing to orchestrate gene expression programmes that underlie collective behaviours. Quorum sensing relies on the production, release, detection and group-level response to extracellular signalling molecules, which are called autoinducers. Recent work has discovered new autoinducers in Gram-negative bacteria, shown how these molecules are recognized by cognate receptors, revealed new regulatory components that are embedded in canonical signalling circuits and identified novel regulatory network designs. In this Review we examine how, together, these features of quorum sensing signal-response systems combine to control collective behaviours in Gram-negative bacteria and we discuss the implications for host-microbial associations and antibacterial therapy.
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U2 - 10.1038/nrmicro.2016.89
DO - 10.1038/nrmicro.2016.89
M3 - Review article
C2 - 27510864
AN - SCOPUS:84982121502
SN - 1740-1526
VL - 14
SP - 576
EP - 588
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 9
ER -