Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost; Josephine R. Chandler; Joshua A.V. Blodgett; Patricia S. Lima; Breck A. Duerkop; Ken Ichi Oinuma; E. Peter Greenberg; Jon Clardy

doi:10.1021/ol902751x

Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost, Josephine R. Chandler, Joshua A.V. Blodgett, Patricia S. Lima, Breck A. Duerkop, Ken Ichi Oinuma, E. Peter Greenberg, Jon Clardy

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

Original language	English (US)
Pages (from-to)	716-719
Number of pages	4
Journal	Organic letters
Volume	12
Issue number	4
DOIs	https://doi.org/10.1021/ol902751x
State	Published - Feb 19 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol902751x

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title = "Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264",

abstract = "(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.",

author = "Seyedsayamdost, {Mohammad R.} and Chandler, {Josephine R.} and Blodgett, {Joshua A.V.} and Lima, {Patricia S.} and Duerkop, {Breck A.} and Oinuma, {Ken Ichi} and {Peter Greenberg}, E. and Jon Clardy",

year = "2010",

month = feb,

day = "19",

doi = "10.1021/ol902751x",

language = "English (US)",

volume = "12",

pages = "716--719",

journal = "Organic letters",

issn = "1523-7060",

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T1 - Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

AU - Seyedsayamdost, Mohammad R.

AU - Chandler, Josephine R.

AU - Blodgett, Joshua A.V.

AU - Lima, Patricia S.

AU - Duerkop, Breck A.

AU - Oinuma, Ken Ichi

AU - Peter Greenberg, E.

AU - Clardy, Jon

PY - 2010/2/19

Y1 - 2010/2/19

N2 - (Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

AB - (Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

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DO - 10.1021/ol902751x

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SP - 716

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JO - Organic letters

JF - Organic letters

IS - 4

ER -

Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Abstract

All Science Journal Classification (ASJC) codes

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