Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost, Josephine R. Chandler, Joshua A.V. Blodgett, Patricia S. Lima, Breck A. Duerkop, Ken Ichi Oinuma, E. Peter Greenberg, Jon Clardy

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

Original languageEnglish (US)
Pages (from-to)716-719
Number of pages4
JournalOrganic letters
Issue number4
StatePublished - Feb 19 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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