Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology

L. P. McGuinness; Y. Yan; A. Stacey; D. A. Simpson; L. T. Hall; D. Maclaurin; S. Prawer; P. Mulvaney; J. Wrachtrup; F. Caruso; R. E. Scholten; L. C.L. Hollenberg

doi:10.1109/IQEC-CLEO.2011.6194042

Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology

L. P. McGuinness, Y. Yan, A. Stacey, D. A. Simpson, L. T. Hall, D. Maclaurin, S. Prawer, P. Mulvaney, J. Wrachtrup, F. Caruso, R. E. Scholten, L. C.L. Hollenberg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

We have demonstrated optically detected magnetic resonance of individual fluorescent nanodiamond nitrogen-vacancy centres inside living human HeLa cells, and measured their spin levels and spin coherence times while tracking their location and orientation with nanoscale precision. Quantum coherence was measured through Rabi and spin-echo sequences over long (>10 h) periods, and orientation was tracked with 1° angular precision in 89 ms acquisition time. Individual centres were identified optically by their electron spin resonance spectrum, allowing simultaneous tracking of many otherwise identical flourescent particles. In addition, variation in the decoherence rates was linked to changes in the local environment inside the cells, representing a new non-destructive imaging modality for intracellular biology.

Original language	English (US)
Title of host publication	2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf
Pages	601-602
Number of pages	2
DOIs	https://doi.org/10.1109/IQEC-CLEO.2011.6194042
State	Published - 2011
Externally published	Yes
Event	2011 International Quantum Electronics Conference, IQEC 2011 and Conference on Lasers and Electro-Optics, CLEO Pacific Rim 2011 - Sydney, NSW, Australia Duration: Aug 28 2011 → Sep 1 2011

Publication series

Name	2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.

Conference

Conference	2011 International Quantum Electronics Conference, IQEC 2011 and Conference on Lasers and Electro-Optics, CLEO Pacific Rim 2011
Country/Territory	Australia
City	Sydney, NSW
Period	8/28/11 → 9/1/11

All Science Journal Classification (ASJC) codes

Electrical and Electronic Engineering

Access to Document

10.1109/IQEC-CLEO.2011.6194042

Cite this

McGuinness, L. P., Yan, Y., Stacey, A., Simpson, D. A., Hall, L. T., Maclaurin, D., Prawer, S., Mulvaney, P., Wrachtrup, J., Caruso, F., Scholten, R. E., & Hollenberg, L. C. L. (2011). Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology. In 2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf (pp. 601-602). Article 6194042 (2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.). https://doi.org/10.1109/IQEC-CLEO.2011.6194042

McGuinness, L. P. ; Yan, Y. ; Stacey, A. et al. / Quantum measurement in living cells : Fluorescent diamond nanocrystals for biology. 2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf. 2011. pp. 601-602 (2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.).

@inproceedings{e8b7aac382de4ea996a5f4fa007da41d,

title = "Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology",

abstract = "We have demonstrated optically detected magnetic resonance of individual fluorescent nanodiamond nitrogen-vacancy centres inside living human HeLa cells, and measured their spin levels and spin coherence times while tracking their location and orientation with nanoscale precision. Quantum coherence was measured through Rabi and spin-echo sequences over long (>10 h) periods, and orientation was tracked with 1° angular precision in 89 ms acquisition time. Individual centres were identified optically by their electron spin resonance spectrum, allowing simultaneous tracking of many otherwise identical flourescent particles. In addition, variation in the decoherence rates was linked to changes in the local environment inside the cells, representing a new non-destructive imaging modality for intracellular biology.",

author = "McGuinness, \{L. P.\} and Y. Yan and A. Stacey and Simpson, \{D. A.\} and Hall, \{L. T.\} and D. Maclaurin and S. Prawer and P. Mulvaney and J. Wrachtrup and F. Caruso and Scholten, \{R. E.\} and Hollenberg, \{L. C.L.\}",

year = "2011",

doi = "10.1109/IQEC-CLEO.2011.6194042",

language = "English (US)",

isbn = "9780977565771",

series = "2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.",

pages = "601--602",

booktitle = "2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf",

note = "2011 International Quantum Electronics Conference, IQEC 2011 and Conference on Lasers and Electro-Optics, CLEO Pacific Rim 2011 ; Conference date: 28-08-2011 Through 01-09-2011",

}

McGuinness, LP, Yan, Y, Stacey, A, Simpson, DA, Hall, LT, Maclaurin, D, Prawer, S, Mulvaney, P, Wrachtrup, J, Caruso, F, Scholten, RE & Hollenberg, LCL 2011, Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology. in 2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf., 6194042, 2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf., pp. 601-602, 2011 International Quantum Electronics Conference, IQEC 2011 and Conference on Lasers and Electro-Optics, CLEO Pacific Rim 2011, Sydney, NSW, Australia, 8/28/11. https://doi.org/10.1109/IQEC-CLEO.2011.6194042

Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology. / McGuinness, L. P.; Yan, Y.; Stacey, A. et al.
2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf. 2011. p. 601-602 6194042 (2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Yan, Y.

AU - Stacey, A.

AU - Simpson, D. A.

AU - Hall, L. T.

AU - Maclaurin, D.

AU - Prawer, S.

AU - Mulvaney, P.

AU - Wrachtrup, J.

AU - Caruso, F.

AU - Scholten, R. E.

AU - Hollenberg, L. C.L.

PY - 2011

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AB - We have demonstrated optically detected magnetic resonance of individual fluorescent nanodiamond nitrogen-vacancy centres inside living human HeLa cells, and measured their spin levels and spin coherence times while tracking their location and orientation with nanoscale precision. Quantum coherence was measured through Rabi and spin-echo sequences over long (>10 h) periods, and orientation was tracked with 1° angular precision in 89 ms acquisition time. Individual centres were identified optically by their electron spin resonance spectrum, allowing simultaneous tracking of many otherwise identical flourescent particles. In addition, variation in the decoherence rates was linked to changes in the local environment inside the cells, representing a new non-destructive imaging modality for intracellular biology.

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DO - 10.1109/IQEC-CLEO.2011.6194042

M3 - Conference contribution

AN - SCOPUS:84862097774

SN - 9780977565771

T3 - 2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.

SP - 601

EP - 602

BT - 2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf

Y2 - 28 August 2011 through 1 September 2011

ER -

McGuinness LP, Yan Y, Stacey A, Simpson DA, Hall LT, Maclaurin D et al. Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology. In 2011 Int. Quantum Electr. Conf., IQEC 2011 Conf Lasers Electro-Optics, CLEO Pacific Rim 2011 Incorporating Australasian Conf. on Optics, Lasers Spectrosc. Australian Conf. Optical Fibre Technol.- Conf. 2011. p. 601-602. 6194042. (2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf.). doi: 10.1109/IQEC-CLEO.2011.6194042

Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology

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