Quantitative trait loci that modify the severity of spotting in piebald mice

William J. Pavan, Susanna Mac, Mickie Cheng, Shirley M. Tilghman

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Mice homozygous for the recessive mutation piebald (s) exhibit a white-spotted coat caused by the defective development of neural crest-derived melanocytes. The severity of white spotting varies greatly, depending on the genetic background on which s is expressed. A backcross between two inbred strains of s/s mice that exhibit large differences in the degree of spotting was used to identify six genetic modifiers of piebald spotting on chromosomes 2, 5, 7, 8, 10, and 13. The loci differed in their spatial contribution to spotting on the dorsal versus ventral surfaces of mice; nonadditive interactions were observed between loci on chromosomes 2 and 4. This study underscores the power of using genetic analyses to identify and analyze loci involved in modifying the severity of phenotypic traits in mice.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalGenome Research
Issue number1
StatePublished - Aug 1995

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics


Dive into the research topics of 'Quantitative trait loci that modify the severity of spotting in piebald mice'. Together they form a unique fingerprint.

Cite this