Quantitative Fluxomics of Circulating Metabolites

Sheng Hui; Alexis J. Cowan; Xianfeng Zeng; Lifeng Yang; Tara TeSlaa; Xiaoxuan Li; Caroline Bartman; Zhaoyue Zhang; Cholsoon Jang; Lin Wang; Wenyun Lu; Jennifer Rojas; Joseph Baur; Joshua D. Rabinowitz

doi:10.1016/j.cmet.2020.07.013

Quantitative Fluxomics of Circulating Metabolites

Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa, Xiaoxuan Li, Caroline Bartman, Zhaoyue Zhang, Cholsoon Jang, Lin Wang, Wenyun Lu, Jennifer Rojas, Joseph Baur, Joshua D. Rabinowitz

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

By infusing 15 different ¹³C-isotope tracers, Hui et al. quantify metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Results include interconversion fluxes between circulating metabolites and their contributions to the TCA cycle in 11 major organs. Rapid interconversion among circulating carbon carriers renders internal metabolic activity robust to diet.

Original language	English (US)
Pages (from-to)	676-688.e4
Journal	Cell Metabolism
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2020.07.013
State	Published - Oct 6 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
Physiology
Cell Biology

Keywords

TCA cycle
circulating metabolites
energy metabolism
in vivo flux quantification
isotope tracing
ketogenic diet
metabolic cycling

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10.1016/j.cmet.2020.07.013

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title = "Quantitative Fluxomics of Circulating Metabolites",

abstract = "By infusing 15 different 13C-isotope tracers, Hui et al. quantify metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Results include interconversion fluxes between circulating metabolites and their contributions to the TCA cycle in 11 major organs. Rapid interconversion among circulating carbon carriers renders internal metabolic activity robust to diet.",

keywords = "TCA cycle, circulating metabolites, energy metabolism, in vivo flux quantification, isotope tracing, ketogenic diet, metabolic cycling",

author = "Sheng Hui and Cowan, {Alexis J.} and Xianfeng Zeng and Lifeng Yang and Tara TeSlaa and Xiaoxuan Li and Caroline Bartman and Zhaoyue Zhang and Cholsoon Jang and Lin Wang and Wenyun Lu and Jennifer Rojas and Joseph Baur and Rabinowitz, {Joshua D.}",

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doi = "10.1016/j.cmet.2020.07.013",

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T1 - Quantitative Fluxomics of Circulating Metabolites

AU - Hui, Sheng

AU - Cowan, Alexis J.

AU - Zeng, Xianfeng

AU - Yang, Lifeng

AU - TeSlaa, Tara

AU - Li, Xiaoxuan

AU - Bartman, Caroline

AU - Zhang, Zhaoyue

AU - Jang, Cholsoon

AU - Wang, Lin

AU - Lu, Wenyun

AU - Rojas, Jennifer

AU - Baur, Joseph

AU - Rabinowitz, Joshua D.

PY - 2020/10/6

Y1 - 2020/10/6

N2 - By infusing 15 different 13C-isotope tracers, Hui et al. quantify metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Results include interconversion fluxes between circulating metabolites and their contributions to the TCA cycle in 11 major organs. Rapid interconversion among circulating carbon carriers renders internal metabolic activity robust to diet.

AB - By infusing 15 different 13C-isotope tracers, Hui et al. quantify metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Results include interconversion fluxes between circulating metabolites and their contributions to the TCA cycle in 11 major organs. Rapid interconversion among circulating carbon carriers renders internal metabolic activity robust to diet.

KW - TCA cycle

KW - circulating metabolites

KW - energy metabolism

KW - in vivo flux quantification

KW - isotope tracing

KW - ketogenic diet

KW - metabolic cycling

UR - http://www.scopus.com/inward/record.url?scp=85090059218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85090059218&partnerID=8YFLogxK

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DO - 10.1016/j.cmet.2020.07.013

M3 - Article

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AN - SCOPUS:85090059218

SN - 1550-4131

VL - 32

SP - 676-688.e4

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Quantitative Fluxomics of Circulating Metabolites

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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