Quantitative Fluxomics of Circulating Metabolites

Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa, Xiaoxuan Li, Caroline Bartman, Zhaoyue Zhang, Cholsoon Jang, Lin Wang, Wenyun Lu, Jennifer Rojas, Joseph Baur, Joshua D. Rabinowitz

Research output: Contribution to journalArticle

Abstract

By infusing 15 different 13C-isotope tracers, Hui et al. quantify metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Results include interconversion fluxes between circulating metabolites and their contributions to the TCA cycle in 11 major organs. Rapid interconversion among circulating carbon carriers renders internal metabolic activity robust to diet.

Original languageEnglish (US)
Pages (from-to)676-688.e4
JournalCell Metabolism
Volume32
Issue number4
DOIs
StatePublished - Oct 6 2020

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Keywords

  • TCA cycle
  • circulating metabolites
  • energy metabolism
  • in vivo flux quantification
  • isotope tracing
  • ketogenic diet
  • metabolic cycling

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