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Quantitative flux analysis reveals folate-dependent NADPH production
Jing Fan
, Jiangbin Ye
, Jurre J. Kamphorst
, Tomer Shlomi
, Craig B. Thompson
,
Joshua D. Rabinowitz
Chemistry
Lewis-Sigler Institute for Integrative Genomics
Molecular Biology
High Meadows Environmental Institute
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peer-review
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Dive into the research topics of 'Quantitative flux analysis reveals folate-dependent NADPH production'. Together they form a unique fingerprint.
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Biochemistry, Genetics and Molecular Biology
Oxidoreductase
100%
Dehydrogenase
100%
Adenosine Triphosphate
100%
Cell Proliferation
100%
Carbon Metabolism
100%
Nicotinamide Adenine Dinucleotide Phosphate
100%
Folate Metabolism
100%
Folic Acid
100%
Flux Analysis
100%
10-Formyltetrahydrofolate
100%
Hexose Monophosphate Shunt
100%
Enzyme
50%
Metabolic Pathway
50%
Anabolism
50%
Liquid Chromatography-Mass Spectrometry
50%
Oxidative Stress
50%
Glycolysis
50%
Muscle Contraction
50%
Nucleic Acid Synthesis
50%
Oxidative Phosphorylation
50%
Isoenzyme
50%
Serine
50%
Glutathione
50%
Tetrahydrofolic Acid
50%
Glucose
50%
Keyphrases
Flux Balance Analysis
100%
Folate
100%
NADPH Production
100%
Nicotinamide Adenine Dinucleotide Phosphate (NADPH)
100%
Proliferating Cells
22%
Oxidative Pentose Phosphate Pathway
22%
One-carbon Metabolism
22%
NADP+
22%
Folate Metabolism
22%
Methylenetetrahydrofolate Reductase (MTHFR)
22%
10-formyltetrahydrofolate
22%
Functional Significance
11%
Deuterium
11%
Isozymes
11%
Reducing Power
11%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
11%
Energy Sources
11%
Mathematical Modeling
11%
Neuronal Firing
11%
Oxidative Stress
11%
Glycolysis
11%
Relative Contribution
11%
Knockdown
11%
Complete Oxidation
11%
Mechanical Work
11%
Oxidized Glutathione
11%
5-methyltetrahydrofolate
11%
Malic Enzyme
11%
One-carbon Units
11%
Reductive Biosynthesis
11%
Electrical Work
11%
Cell Sensitivity
11%
Muscle Contraction
11%
Labeled Substrates
11%
NADPH Metabolism
11%
Carbon Labeling
11%
Oxidative Phosphorylation (OXPHOS)
11%
ATP Production
11%
Redox Defense
11%
Chemical Work
11%
Nucleic Acid Synthesis
11%